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Nils Brünner Selected Research

Plasminogen Inactivators

7/2011Cancer therapy trials employing level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.
11/2010Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.
10/2010Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.
10/2008Plasminogen activator inhibitor 1 protects fibrosarcoma cells from etoposide-induced apoptosis through activation of the PI3K/Akt cell survival pathway.
1/2007Lack of association between level of Plasminogen Activator Inhibitor-1 and estimates of tumor angiogenesis in early breast cancer.
10/2005Indication of a role of plasminogen activator inhibitor type I in protecting murine fibrosarcoma cells against apoptosis.
3/2005Expression of urokinase plasminogen activator, its receptor and type-1 inhibitor in malignant and benign prostate tissue.
4/2004Tumor tissue levels of tissue inhibitor of metalloproteinase-1 as a prognostic marker in primary breast cancer.
1/2004XR5967, a novel modulator of plasminogen activator inhibitor-1 activity, suppresses tumor cell invasion and angiogenesis in vitro.

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Nils Brünner Research Topics

Disease

99Neoplasms (Cancer)
01/2021 - 01/2002
69Breast Neoplasms (Breast Cancer)
01/2021 - 01/2002
61Colorectal Neoplasms (Colorectal Cancer)
07/2021 - 01/2002
15Colonic Neoplasms (Colon Cancer)
04/2020 - 01/2002
14Neoplasm Metastasis (Metastasis)
01/2018 - 01/2002
6Glioblastoma (Glioblastoma Multiforme)
01/2019 - 04/2002
5Adenocarcinoma
02/2010 - 09/2004
4Adenoma (Adenomas)
09/2016 - 09/2004
4Carcinoma (Carcinomatosis)
12/2014 - 03/2005
4Rectal Neoplasms (Rectal Cancer)
10/2013 - 01/2002
4Ovarian Neoplasms (Ovarian Cancer)
07/2011 - 01/2002
4Fibrosarcoma
10/2008 - 01/2004
3Astrocytoma (Pilocytic Astrocytoma)
01/2018 - 04/2002
3Glioma (Gliomas)
12/2016 - 04/2002
3Aneuploidy (Aneuploid)
11/2016 - 10/2005
3Carcinogenesis
03/2010 - 01/2005
3Prostatic Neoplasms (Prostate Cancer)
12/2008 - 05/2006
3Primary Myelofibrosis (Myelosclerosis)
11/2003 - 07/2002
2Testicular Neoplasms (Testicular Cancer)
06/2015 - 12/2008
2Body Weight (Weight, Body)
01/2015 - 10/2007
2Obesity
01/2015 - 01/2008
2Fibrosis (Cirrhosis)
09/2014 - 11/2003
2Disease Progression
10/2010 - 10/2009
2Myeloproliferative Disorders (Myeloproliferative Disorder)
11/2003 - 10/2003

Drug/Important Bio-Agent (IBA)

56Tissue Inhibitor of Metalloproteinase-1IBA
01/2019 - 01/2002
46Biomarkers (Surrogate Marker)IBA
01/2021 - 01/2002
39Proteins (Proteins, Gene)FDA Link
07/2020 - 10/2005
23Irinotecan (Camptosar)FDA LinkGeneric
07/2020 - 07/2007
19Plasminogen Activator Inhibitor 1IBA
07/2011 - 01/2002
18Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
11/2015 - 01/2002
14AnthracyclinesIBA
02/2016 - 12/2006
13Messenger RNA (mRNA)IBA
04/2020 - 04/2002
13Plasminogen Activators (Plasminogen Activator)IBA
12/2010 - 01/2002
12ParaffinIBA
04/2016 - 01/2008
11Pharmaceutical PreparationsIBA
05/2020 - 01/2011
10Fluorouracil (Carac)FDA LinkGeneric
04/2020 - 12/2006
10Oxaliplatin (Eloxatin)FDA LinkGeneric
11/2016 - 01/2011
9Formaldehyde (Formol)FDA Link
04/2016 - 10/2009
9Matrix Metalloproteinases (MMPs)IBA
09/2014 - 06/2002
9Tumor Biomarkers (Tumor Markers)IBA
08/2013 - 06/2003
9Plasminogen InactivatorsIBA
07/2011 - 01/2004
8Estrogen ReceptorsIBA
08/2016 - 05/2002
8Hormones (Hormone)IBA
04/2015 - 01/2002
7Type I DNA Topoisomerases (Topoisomerase I)IBA
06/2019 - 01/2013
7Tissue Inhibitor of MetalloproteinasesIBA
04/2015 - 01/2002
7Carcinoembryonic AntigenIBA
10/2013 - 08/2006
7Tissue ExtractsIBA
08/2013 - 01/2002
6Epirubicin (Ellence)FDA LinkGeneric
07/2021 - 02/2008
6Docetaxel (Taxotere)FDA Link
01/2021 - 05/2014
6taxaneIBA
01/2021 - 02/2015
6AntibodiesIBA
09/2016 - 01/2004
6Urokinase Plasminogen Activator ReceptorsIBA
11/2015 - 05/2002
5TamoxifenFDA LinkGeneric
08/2016 - 07/2004
5AntigensIBA
06/2015 - 07/2004
5Cyclophosphamide (Cytoxan)FDA LinkGeneric
02/2012 - 12/2006
4MicroRNAs (MicroRNA)IBA
01/2021 - 01/2011
4Leucovorin (Folinic Acid)FDA Link
04/2020 - 07/2007
4Taxoids (Taxanes)IBA
12/2018 - 04/2013
4Estrogens (Estrogen)FDA Link
08/2016 - 12/2008
4Progesterone Receptors (Progesterone Receptor)IBA
12/2014 - 12/2008
4Monoclonal AntibodiesIBA
05/2014 - 01/2006
4Peptide Hydrolases (Proteases)FDA Link
08/2013 - 07/2003
4Methotrexate (Mexate)FDA LinkGeneric
02/2012 - 12/2006
4Biological ProductsIBA
11/2010 - 07/2003
4PlasminogenIBA
10/2010 - 07/2003
3RNA (Ribonucleic Acid)IBA
01/2021 - 11/2011
3Member 2 Subfamily G ATP Binding Cassette TransporterIBA
07/2020 - 01/2016
3Adenosine Triphosphate (ATP)IBA
01/2020 - 01/2016
3EnzymesIBA
12/2016 - 01/2002
3Cetuximab (Erbitux)FDA Link
09/2016 - 06/2015
3Type II DNA Topoisomerases (Topoisomerase II)IBA
04/2015 - 02/2011
3thiamine triphosphorate (TTP)IBA
05/2014 - 07/2007
3PlatinumIBA
03/2014 - 05/2010
3Metalloproteases (Metalloproteinases)IBA
08/2013 - 01/2005
3Peptides (Polypeptides)IBA
07/2011 - 04/2002
3SteroidsIBA
08/2010 - 01/2002
2ATP-Binding Cassette Transporters (ABC Transporters)IBA
01/2020 - 09/2017
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2019 - 11/2010
2Topoisomerase InhibitorsIBA
01/2019 - 09/2013
2ImmunosorbentsIBA
12/2016 - 01/2002
2ErbB Receptors (EGF Receptor)IBA
09/2016 - 12/2013
2Epidermal Growth Factor (EGF)IBA
09/2016 - 12/2008
2Trastuzumab (Herceptin)FDA Link
04/2013 - 12/2008
2DNA (Deoxyribonucleic Acid)IBA
11/2011 - 01/2002
2Levonorgestrel (Plan B)FDA LinkGeneric
07/2011 - 11/2010
2Matrix Metalloproteinase 9 (Gelatinase B)IBA
12/2010 - 02/2010
2CarbohydratesIBA
02/2010 - 01/2008
2Prostate-Specific Antigen (Semenogelase)IBA
12/2008 - 05/2006
2Tissue Inhibitor of Metalloproteinase-2IBA
10/2008 - 11/2003
2Etoposide (VP 16)FDA LinkGeneric
10/2008 - 05/2005
2FibrinolysinFDA Link
10/2005 - 07/2003
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2002 - 04/2002
1Circular RNAIBA
01/2021

Therapy/Procedure

26Drug Therapy (Chemotherapy)
12/2018 - 05/2005
25Therapeutics
01/2021 - 06/2002
7Adjuvant Chemotherapy
04/2015 - 02/2008
2Lasers (Laser)
01/2018 - 06/2013
2Combination Drug Therapy (Combination Chemotherapy)
01/2010 - 07/2007
2Aftercare (After-Treatment)
08/2008 - 02/2008
2Blood Transfusion (Blood Transfusions)
10/2006 - 01/2002